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A ≥20% decrease in central endothelial cell density (CECD) was reported in 0% (ARTEMIS 1 and 2) of patients after the first administration of the 10ug implant, in 2.3% and 0.6% of patients after the second administration, in 4.1% and 3.5% after the third administration and in 10.2% and 8.1% of respective study eyes at month 20

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The Absorbance was read at 340 nm every 10 s for 1 min in a spectrometer (Bio-Tek) to calculate the activity